Protein Details: P2X purinoceptor 2

Protein ID

ICDB_Pro_0565

Protein Name

P2X purinoceptor 2

Gene Name

P2rx2

Organism

Rattus norvegicus (Rat)

Length

472 amino acids

AlphaFoldDB

AF-P49653-F1-model_v4.pdb

Function

ATP-gated nonselective transmembrane cation channel permeable to potassium; sodium and calcium. Activation by extracellular ATP induces a variety of cellular responses; such as excitatory postsynaptic responses in sensory neurons; neuromuscular junctions (NMJ) formation; hearing; perception of taste and peristalsis. In the inner ear; regulates sound transduction and auditory neurotransmission; outer hair cell electromotility; inner ear gap junctions; and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle (By similarity).

Sequence

MVRRLARGCWSAFWDYETPKVIVVRNRRLGFVHRMVQLLILLYFVWYVFIVQKSYQDSETGPESSIITKVKGITMSEDKVWDVEEYVKPPEGGSVVSIITRIEVTPSQTLGTCPESMRVHSSTCHSDDDCIAGQLDMQGNGIRTGHCVPYYHGDSKTCEVSAWCPVEDGTSDNHFLGKMAPNFTILIKNSIHYPKFKFSKGNIASQKSDYLKHCTFDQDSDPYCPIFRLGFIVEKAGENFTELAHKGGVIGVIINWNCDLDLSESECNPKYSFRRLDPKYDPASSGYNFRFAKYYKINGTTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSIGVGSFLCDWILLTFMNKNKLYSHKKFDKVRTPKHPSSRWPVTLALVLGQIPPPPSHYSQDQPPSPPSGEGPTLGEGAELPLAVQSPRPCSISALTEQVVDTLGQHMGQRPPVPEPSQQDSTSTDPKGLAQL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 69; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 71; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 184; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 284; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 288; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 290; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 308; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"

Disease

Location

High levels in pituitary and vas deferens. Lower extent in spinal cord; bladder; brain; adrenal; testis; sensory epithelia from the inner ear.

DOI ID

10.1038/371519a0; 10.1016/s0014-5793(97)00128-2; 10.1006/bbrc.1995.1998; 10.1113/jphysiol.1996.sp021777; 10.1016/s0014-2999(99)00350-7; 10.1016/s0014-2999(03)02038-7; 10.1016/j.jmb.2004.06.092; 10.1529/biophysj.106.101048

RefSeq

NP_446108.2 [P49653-1]